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Dirlotapide

medicationWhy has my veterinarian prescribed this medicine?

Dirlotapide is used to help reduce weight in dogs. Your veterinarian  may prescribe dirlotapide if your pet is obese or overweight. Dirlotapide is used as part of an overall weight reduction programme, which also includes appropriate dietary changes and exercise. It is important that measures are continued after the treatment course is finished to avoid rebound weight gain.

How does this medicine work?

Dirlotapide blocks a protein in the intestine that is involved in the absorption of fats in the food ingested. The absorption of fats from the gut is decreased and this change in fat absorption has an appetite suppressant effect.

How do I give this medication?

- Give this medication to your pet as directed by your veterinarian. READ THE LABEL CAREFULLY. Your dog’s weight must be monitored regularly during treatment and the dose administered will be adjusted according to weight loss achieved.

- This medicine can be administered with or without food. 

- Try to give this medication at about the same time each day.

- Wash your hands after handling the medication. This medicine may cause eye irritation. If accidental eye exposure occurs, flush eyes immediately with clean water. In case of accidental ingestion seek medical advice immediately and show the package leaflet of label to the physician.

- DO NOT give the pet more medicine than directed and DO NOT give more often than directed.

- Dirlotapide can be administered for up to 12 months.

- Try not to miss giving any doses.

What do I do if I miss giving a dose?

Give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. Do not give the pet two doses at once.

How do I store this medicine?

Keep this medicine out of reach and sight of children. Store this medicine in a cool, dry place at room temperature and away from heat and direct sunlight. The product should be used within 3 months of opening the container.

Potential side effects

- Although a drug has potential side effects, it does not mean that there is necessarily a high risk of any of these occurring. Tell your veterinarian if you think your pet may be pregnant or is lactating.

- Dirlotapide must not be used in growing animals, animals with liver disease, and animals with other diseases that may cause increased weight gain such as hyperthyroidism or hyperadrenocorticism. DO NOT use this medicine in CATS.

- Potential side effects of dirlotapide include vomiting, lethargy, anorexia and diarrhoea. Notify your veterinarian if side effects or excessive weight loss appear and remain troublesome.

- Other side effects may occur, if you notice anything unusual, contact your veterinarian.

Possible drug interactions

- Make sure to tell your veterinarian what other medication you are giving to your pet.

- Quite often your veterinarian may prescribe two different medications, even if a drug interaction may occur. In this case, your veterinarian may vary the dose and/or monitor your pet more closely.

- Drugs may interact such that they can cause an increased or decreased effect or side effects. Although drug interactions may occur, it does not mean that there is necessarily a high risk of any of these occurring.

- Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.

© Copyright 2025 LifeLearn Inc. Used and/or modified with permission under license. This content written by LifeLearn Animal Health (LifeLearn Inc.) is licensed to this practice for the personal use of our clients. Any copying, printing or further distribution is prohibited without the express written consent of LifeLearn. This content does not contain all available information for any referenced medications and has not been reviewed by the FDA Center for Veterinary Medicine, or Health Canada Veterinary Drugs Directorate. This content may help answer commonly asked questions, but is not a substitute for medical advice, or a proper consultation and/or clinical examination of your pet by a veterinarian. Please contact your veterinarian if you have any questions or concerns about your pet’s health. Created on Jul 26, 2015.